Multi-purpose in vivo Imaging in Intracranial Tumor Models to Support Clinical Translation in Neuro-oncology

Presenters: Anderson Clark, Ph.D. | Director of in vivo Pharmacology, EMD Serono Research & Development Institute

Patrick McConville, Ph.D. | Vice President, Non-clinical Research Services, Invicro 

Intracranial tumor models have become the discovery standard for in vivo proof of concept, efficacy screening and candidate selection. These models require sophisticated and precise in vivo imaging including expert use of MRI and bioluminescence for tumor burden quantification.  

The use of other sophisticated MRI, PET and SPECT applications has greatly expanded the utility and impact of the models for clinical translation. These imaging applications enhance the development of next generation therapeutics including antibodies, exosomes and nanoparticles for treatment of brain cancers. 

During this webinar, the presenters will discuss:

  • in vivo imaging applications across MRI, bioluminescence imaging (BLI) for quantification of tumor burden in Cell Line-Derived Xenograft and Patient-Derived Xenografts intracranial models 
  • The use of PET and SPECT to study treatment entity biodistribution and tumor targeting in neuro-oncology 
  • The use of contrast-enhanced MRI to interrogate blood-brain barrier penetration and correlation with therapeutic response for cMET inhibitors 

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Clark 2


Director of In Vivo Pharmacology, EMD Serono Research & Development Institute

Dr. Clark is an in vivo pharmacologist with over 15 years of experience in preclinical oncology research.  He serves on project teams involving novel anti-cancer small molecules and biologics to drive critical decision-making from discovery through development and into life-cycle management.  Dr. Clark has extensive experience utilizing rodent models of cancer in studies of pharmacokinetic/pharmacodynamic relationships, efficacy and biomarker investigation with a focus on study design and execution, data analysis and interpretation, and forward and reverse clinical translation. After earning his Ph.D. from Penn State University, Dr. Clark held a postdoctoral fellowship with the National Institute of Health and Medical Research in France followed by postdoctoral training in the Department of Biochemistry at Washington State University. 



Vice President, Non-clinical Research Services, Invicro

Dr. McConville has 20 years experience in multi-modality drug discovery and translational imaging working across all major disease areas with a particular focus in oncology.  After receiving his Ph.D. in Medical Physics (Queensland University of Technology, Australia) and conducting postdoctoral work at the NIH, Dr. McConville cofounded the first translational imaging CRO. In 2014, Dr. McConville launched a new state-of-the-art in vivo imaging center in La Jolla, CA, and currently oversees commercial and academic work there.