Presenters: Anderson Clark, Ph.D. | Director of in vivo Pharmacology, EMD Serono Research & Development Institute
Patrick McConville, Ph.D. | Vice President, Non-clinical Research Services, Invicro
Intracranial tumor models have become the discovery standard for in vivo proof of concept, efficacy screening and candidate selection. These models require sophisticated and precise in vivo imaging including expert use of MRI and bioluminescence for tumor burden quantification.
The use of other sophisticated MRI, PET and SPECT applications in these models has greatly expanded the utility and impact of the models for clinical translation. These imaging applications are enhancing the development of next generation therapeutics including antibodies, exosomes and nanoparticles for treatment of brain cancers.
During this webinar, the presenters will discuss:
Dr. Clark is an in vivo pharmacologist with over 15 years of experience in preclinical oncology research. He and scientists in his group serve on project teams involving novel anti-cancer small molecules and biologics where they drive critical decision-making from discovery through development and into life-cycle management. Dr. Clark has over 15 years of experience utilizing rodent models of cancer in studies of pharmacokinetic/pharmacodynamic relationships, efficacy and biomarker investigation and confirmation, with a focus on study design and execution, data analysis and interpretation and forward and reverse clinical translation. After earning his Ph.D. from Penn State University, Dr. Clark held a postdoctoral fellowship with the National Institutes of Health and Medical Research in France followed by postdoctoral training in the Department of Biochemistry at Washington State University.
Dr. McConville has 20 years experience in multi-modality drug discovery and translational imaging, working across all major disease areas, with a particular focus in oncology. After receiving his Ph.D. in Medical Physics (Queensland University of Technology, Australia) and conducting postdoctoral work at the NIH, Dr. McConville cofounded the first translational imaging CRO. In 2014, Dr. McConville launched a new state of the art in vivo imaging center in La Jolla, CA, and currently oversees continuing commercial and academic work there.