Development of Novel PET Radioligands for PET Imaging Applications ​

Presenter: Lisa Wells, BSc Hons, Ph.D. | Head of Discovery CNS Applications, Invicro

The development and optimization of novel radioligands for drug development applications is critical to move new compounds from bench to bedside. However, in a similar manner to drug development, the process can carry risk. 

By sharing the example of a novel radioligand development program for Sirtuin-2, using in vitro data to evaluate the level of target expression (maximum binding site, Bmax) and binding affinity (Kd), we assess whether the biological target will be tractable for an imaging study. Combining this knowledge with radiolabeling feasibility of the candidate radioligands and supportive in vitro characterization, biomathematical modelling methods are performed in order to identify the compounds that are amenable to PET/SPECT labeling and to rank them into likely successful candidates. Subsequent phases include radiolabeling of the chosen candidate(s), evaluation of the radioligand(s) in an appropriate preclinical species and translation into human. Here, we review the steps to reduce this attrition at an early stage, leading to a successful radioligand development program.

During this webinar, the presenter will:

  1. Provide an overview of a typical study design for the development of a suitable PET radioligand for a novel target in CNS disease models
  2. Explain the importance of determining target expression in the tissue(s) of interest and candidate ligand characteristics prior to in vivo imaging
  3. Explain how data is analyzed to answer “Morgan’s Pillars of Survival” for lead compounds in preclinical animal models, non-human primates and human subjects
Wednesday, October 14
10:30am EDT

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Lisa

LISA WELLS, BSC HONS, PH.D.

Head of CNS Discovery, Invicro

With over 15 years experience in the field of pharmacology, Dr. Well's  expertise is designing and applying pharmacological techniques from tissue studies to translational PET imaging to evaluate novel radioligands and understand target engagement/ pharmacodynamic outcome measures in vivo. She holds a first-class honours degree in medical biochemistry prior to completing a Ph.D. in Neuropharmacology at the University of Surrey. In 2007, Dr. Wells joined the nuclear imaging field taking a role at GlaxoSmithKline Clinical Imaging Centre where she applied preclinical molecular imaging techniques to support drug discovery and development. Later transitioning to Head of Biology at Imanova Centre for Imaging Sciences (2011). At Invicro, Dr. Wells uses her knowledge of the pharmaceutical industry to lead the global Discovery CNS Applications, using her expertise to support optimal study design to provide clear study outcomes with a view to translating studies to the clinic.