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Rapid in vivo Screening of Gene Delivery, Anticancer Efficacy and Cell Trafficking Using Bioluminescence Imaging

Rapid, precise and non-invasive in vivo assessment of gene therapy and antitumor efficacy in deep tissue tumor models is feasible through the use of luciferase reporters and bioluminescence imaging (BLI). BLI is well-suited for quantifying tumor growth and treatment pharmacodynamics in orthotopic, hematologic and metastasis models of cancer.

Since luciferase reporters can be relatively easily and effectively incorporated into these biologic platforms, BLI has become the preferred platform for screening prior to moving into early clinical studies. Furthermore, luciferase is used to test gene reporter platforms using translational gene reporters, such as HSV-TK.

In this webinar, Dr. McConville will provide an overview of state-of-the art-applications that utilize luciferase reporters and bioluminescent imaging, including gene delivery and oncolytic virus examples. Dr. Timberlake will showcase bioluminescence imaging based screening approaches to interrogate CAR-T cell efficacy, tracking and activation.

This webinar reviews:

  • How luciferase is used as a sensitive gene reporter for the detection of cells and biological therapies.  
  • How to perform efficient and quantitative in vivo screening of:
    • Gene delivery
    • Cell tracking, including CAR-T cells
    • Efficacy in deep tissue tumor models
Patrick McConville PhD | VP, Non-Clinical Research Services, Invicro
Nina Timberlake PhD | Senior Scientist, Poseida Therapeutics

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About The Speakers

Patrick McConville, Ph.D.
VP, Non-Clinical Research Services, Invicro

Dr. McConville has 20 years experience in multi-modality drug discovery and translational imaging working across all major disease areas with a particular focus in oncology.  After receiving his PhD in Medical Physics (Queensland University of Technology, Australia) and conducting postdoctoral work at the NIH, Dr. McConville cofounded the first translational imaging CRO. In 2014, Dr. McConville launched a new state-of-the-art in vivo imaging center in La Jolla, CA and currently oversees commercial and academic work there in his roles at the Konica Minolta company, Invicro and UCSD.

Nina Timerlake, Ph.D.
Senior Scientist, Poseida Therapeutics

Dr. Timberlake has 10 years of experience developing gene and cell therapies for cancer and rare diseases. She received a doctorate in Medical and Molecular Pharmacology from UCLA and subsequently moved to San Diego to complete a Postdoctoral Fellowship at the Scripps Research Institute. Originally trained in viral gene delivery, Dr. Timberlake's expertise as part of the Gene Therapy team at Poseida Therapeutics helps to develop the next generation of cell therapies using cutting-edge non-viral gene delivery technology. Her projects include preclinical development of novel hematopoietic stem cell and CAR-T cell therapeutics.